You won't find 2h weapons with defense, and you shouldn't be using one anyway. The rune is there to give you the defensive stats on an otherwise offensively budgeted slot, but you want the best offensive power you can muster from the weapon itself since you don't receive much bonus threat from ability uses themselves (like most tanks) and instead receive most of it from a threat multiplier based on your offensive power.
Personally I just used my heirloom axe all the way to 80 and then bought a titansteel destroyer to runeforge for starting up tanking 4srs.
Edited, Jun 1st 2010 7:18pm by Norellicus